Transgenic Animals Applications Ppt

Organisms containing integrated sequences of cloned DNA transgenes transferred using techniques of genetic engineering to include those of gene transfer and gene substitution are called transgenic animals.

Transgenic animals applications ppt. One of them is the ability to engineer transgenic animals. This would enable not only the addition of gene constructs but. A transgenic animal is one that carries a foreign gene that has been deliberately inserted into its genome.

Let us have a detailed look at the process importance and applications of transgenic animals. 356 have been used as experimental animals for production of transgenic fish. Ful in generating transgenic animals but may have applications as transient gene-expression systems 15.

Transgenic Animals Synthetic modified or other foreign genes can be introduced into animals and plants and the resulting transgenic organisms can be used to study the function of the genes for example by insertional mutagenesis to produce novel products or to serve as animal models for studies of inherited human diseases. The transgenic fish are being promoted as the first marketable transgenic animals for human consumption. Transgenic animals that produce useful biological products can be created by the introduction of the portion of DNA or genes which codes for a particular product such as human protein a-1-antitrypsin used to treat emphysema tissue plasmogen activator goat blood clotting factors VIII and IX sheep and lactoferrin cow.

Methodology Retrovirus vector DNA microinjection Engineered embryonic stem cell Cre. A transgenic animal is animal whose chromosomes have been changed to carry the. Several different fish spe-cies including channel catfish common carp goldfish Japanese medaka loach northern pike rainbow trout salmon tilapia walleye and zebrafish for review.

Foreign genes are inserted into the germ line of the animal so it can be transmitted to the progeny. The first genetically modified organism was a bacteria created in 1973 by Stanley N. The creations of many transgenic animals were subsequently reported in 1985s 6.

Selection of Fish Species. 1 Assistant Professor 2 Associate Professor Department of Pharmacology Pravara I. Using transgenic mice as test systems eg protein CFTR secretion.